Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.immuni.2018.06.008
Journal or Publication Title: Immunity
Volume: 49
Number: 2
Page Range: 326-341.e7
Date: 2018
Divisions: Immune Imaging
Depositing User: General Admin
Identification Number: 10.1016/j.immuni.2018.06.008
ISSN: 10747613
Date Deposited: 03 Jan 2021 22:59
Abstract:

The maintenance of appropriate arterial tone is critically important for normal physiological arterial function. However, the cellular and molecular mechanisms remain poorly defined. Here, we have shown that in the mouse aorta, resident macrophages prevented arterial stiffness and collagen deposition in the steady state. Using phenotyping, transcriptional profiling, and targeted deletion of Csf1r, we have demonstrated that these macrophages-which are a feature of blood vessels invested with smooth muscle cells (SMCs) in both mouse and human tissues-expressed the hyaluronan (HA) receptor LYVE-l. Furthermore, we have shown they possessed the unique ability to modulate collagen expression in SMCs by matrix metalloproteinase MMP-9-dependent proteolysis through engagement of LYVE-1 with the HA pericellular matrix of SMCs. Our study has unveiled a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.

Keywords: LYVE-1; arterial stiffness; artery; hyaluronan; macrophage; smooth muscle cell.

Copyright © 2018 Elsevier Inc. All rights reserved.

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Lim, Hwee Ying
UNSPECIFIED
Lim, Sheau Yng
UNSPECIFIED
Tan, Chek Kun
UNSPECIFIED
Thiam, Chung Hwee
UNSPECIFIED
Goh, Chi Ching
UNSPECIFIED
Carbajo, Daniel
UNSPECIFIED
Chew, Samantha Hui Shang
UNSPECIFIED
See, Peter
UNSPECIFIED
Chakarov, Svetoslav
UNSPECIFIED
Wang, Xiao Nong
UNSPECIFIED
Lim, Li Hui
UNSPECIFIED
Johnson, Louise A.
UNSPECIFIED
Lum, Josephine
UNSPECIFIED
Fong, Chui Yee
UNSPECIFIED
Bongso, Ariff
UNSPECIFIED
Biswas, Arijit
UNSPECIFIED
Goh, Chern
UNSPECIFIED
Evrard, Maximilien
UNSPECIFIED
Yeo, Kim Pin
UNSPECIFIED
Basu, Ranu
UNSPECIFIED
Wang, Jun Kit
UNSPECIFIED
Tan, Yingrou
UNSPECIFIED
Jain, Rohit
UNSPECIFIED
Tikoo, Shweta
UNSPECIFIED
Choong, Cleo
UNSPECIFIED
Weninger, Wolfgang
UNSPECIFIED
Poidinger, Michael
UNSPECIFIED
Stanley, Richard E.
UNSPECIFIED
Collin, Matthew
UNSPECIFIED
Tan, Nguan Soon
UNSPECIFIED
Ng, Lai Guan
UNSPECIFIED
Jackson, David G.
UNSPECIFIED
Ginhoux, Florent
UNSPECIFIED
Angeli, Véronique
UNSPECIFIED
Last Modified: 03 Jan 2021 22:59
URI: https://eprints.centenary.org.au/id/eprint/500

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