Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development.
Full text not available from this repository.Item Type: | Article |
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Status: | Published |
Official URL: | https://doi.org/10.1016/j.devcel.2018.07.005 |
Journal or Publication Title: | Developmental Cell |
Volume: | 46 |
Number: | 4 |
Page Range: | 504-517.e7 |
Date: | 2018 |
Divisions: | Gene and Stem Cell Therapy |
Depositing User: | General Admin |
Identification Number: | 10.1016/j.devcel.2018.07.005 |
ISSN: | 15345807 |
Date Deposited: | 03 Jan 2021 23:04 |
Abstract: | Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions. Keywords: myelin; neural development; neural progenitors; oligodendrocyte; oligodendrocyte precursor cell; pericyte; platelet-derived growth factor receptor alpha; single-cell RNA-seq; transcription factors; transcriptomics. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved. |
Creators: | Creators Email Marques, Sueli UNSPECIFIED van Bruggen, David UNSPECIFIED Vanichkina, Darya Pavlovna UNSPECIFIED Floriddia, Elisa Mariagrazia UNSPECIFIED Munguba, Hermany UNSPECIFIED Väremo, Leif UNSPECIFIED Giacomello, Stefania UNSPECIFIED Falcão, Ana Mendanha UNSPECIFIED Meijer, Mandy UNSPECIFIED Björklund, Åsa Kristina UNSPECIFIED Hjerling-Leffler, Jens UNSPECIFIED Taft, Ryan James UNSPECIFIED Castelo-Branco, Gonçalo UNSPECIFIED |
Last Modified: | 03 Jan 2021 23:04 |
URI: | https://eprints.centenary.org.au/id/eprint/489 |
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