Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.devcel.2018.07.005
Journal or Publication Title: Developmental Cell
Volume: 46
Number: 4
Page Range: 504-517.e7
Date: 2018
Divisions: Gene and Stem Cell Therapy
Depositing User: General Admin
Identification Number: 10.1016/j.devcel.2018.07.005
ISSN: 15345807
Date Deposited: 03 Jan 2021 23:04
Abstract:

Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions.

Keywords: myelin; neural development; neural progenitors; oligodendrocyte; oligodendrocyte precursor cell; pericyte; platelet-derived growth factor receptor alpha; single-cell RNA-seq; transcription factors; transcriptomics.

Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Creators:
Creators
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Marques, Sueli
UNSPECIFIED
van Bruggen, David
UNSPECIFIED
Vanichkina, Darya Pavlovna
UNSPECIFIED
Floriddia, Elisa Mariagrazia
UNSPECIFIED
Munguba, Hermany
UNSPECIFIED
Väremo, Leif
UNSPECIFIED
Giacomello, Stefania
UNSPECIFIED
Falcão, Ana Mendanha
UNSPECIFIED
Meijer, Mandy
UNSPECIFIED
Björklund, Åsa Kristina
UNSPECIFIED
Hjerling-Leffler, Jens
UNSPECIFIED
Taft, Ryan James
UNSPECIFIED
Castelo-Branco, Gonçalo
UNSPECIFIED
Last Modified: 03 Jan 2021 23:04
URI: https://eprints.centenary.org.au/id/eprint/489

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