Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models

Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.dci.2018.07.022
Journal or Publication Title: Developmental & Comparative Immunology
Volume: 88
Page Range: pp. 169-172
Date: 2018
Divisions: Immune-Vascular Interactions
Tuberculosis
Depositing User: General Admin
Identification Number: 10.1016/j.dci.2018.07.022
ISSN: 0145305X
Date Deposited: 03 Jan 2021 23:05
Abstract:

Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.

Keywords: Foam cell; Granuloma; Lipid; Mycobacterium; Pathogenesis; Zebrafish.

Copyright © 2018 Elsevier Ltd. All rights reserved.

Creators:
Creators
Email
Johansen, Matt D.
UNSPECIFIED
Kasparian, Joshua A.
UNSPECIFIED
Hortle, Elinor
UNSPECIFIED
Britton, Warwick J.
UNSPECIFIED
Purdie, Auriol C.
UNSPECIFIED
Oehlers, Stefan H.
UNSPECIFIED
Last Modified: 03 Jan 2021 23:05
URI: https://eprints.centenary.org.au/id/eprint/488

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