CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.celrep.2018.08.094
Journal or Publication Title: Cell Reports
Volume: 25
Number: 1
Page Range: 68-79.e4
Date: 2018
Divisions: Liver Immunology
Depositing User: General Admin
Identification Number: 10.1016/j.celrep.2018.08.094
ISSN: 22111247
Date Deposited: 03 Jan 2021 23:07
Abstract:

Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm cell development, we examined various conditions for their formation. Although liver Trm cells were found in naive mice, their presence was dictated by antigen specificity and required IL-15. Liver Trm cells also formed after adoptive transfer of in vitro-activated but not naive CD8+ T cells, indicating that activation was essential but that antigen presentation within the liver was not obligatory. These Trm cells patrolled the liver sinusoids with a half-life of 36 days and occupied a large niche that could be added to sequentially without effect on subsequent Trm cell cohorts. Together, our findings indicate that liver Trm cells form as a normal consequence of CD8+ T cell activation during essentially any infection but that inflammatory and antigenic signals preferentially tailor their development.

Keywords: T cell memory; liver; liver immunology; malaria; niche; tissue-resident memory.

Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Creators:
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Holz, Lauren E.
UNSPECIFIED
Prier, Julia E.
UNSPECIFIED
Freestone, David
UNSPECIFIED
Steiner, Thiago M.
UNSPECIFIED
English, Kieran
UNSPECIFIED
Johnson, Darryl N.
UNSPECIFIED
Mollard, Vanessa
UNSPECIFIED
Cozijnsen, Anton
UNSPECIFIED
Davey, Gayle M.
UNSPECIFIED
Godfrey, Dale I.
UNSPECIFIED
Yui, Katsuyuki
UNSPECIFIED
Mackay, Laura K.
UNSPECIFIED
Lahoud, Mireille H.
UNSPECIFIED
Caminschi, Irina
UNSPECIFIED
McFadden, Geoffrey I.
UNSPECIFIED
Bertolino, Patrick
UNSPECIFIED
Fernandez-Ruiz, Daniel
UNSPECIFIED
Heath, William R.
UNSPECIFIED
Last Modified: 03 Jan 2021 23:07
URI: https://eprints.centenary.org.au/id/eprint/486

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