An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis

An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.cell.2018.08.013
Journal or Publication Title: Cell
Volume: 175
Number: 2
Page Range: 530-543.e24
Date: 2018
Divisions: Epigenetics and RNA Biology
Immune Imaging
Liver Enzymes in Metabolism and Inflammation
Liver Immunology
Depositing User: General Admin
Identification Number: 10.1016/j.cell.2018.08.013
ISSN: 00928674
Date Deposited: 03 Jan 2021 23:09
Abstract:

The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans.

Keywords: Parvoviridae; chronic kidney disease; fibrosis; inclusion body nephropathy; parvovirus; tubulointerstitial fibrosis; viral metagenomics.

Copyright © 2018 Elsevier Inc. All rights reserved.

Creators:
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Roediger, Ben
UNSPECIFIED
Lee, Quintin
UNSPECIFIED
Tikoo, Shweta
UNSPECIFIED
Cobbin, Joanna C.A.
UNSPECIFIED
Henderson, James M.
UNSPECIFIED
Jormakka, Mika
UNSPECIFIED
O’Rourke, Matthew B.
UNSPECIFIED
Padula, Matthew P.
UNSPECIFIED
Pinello, Natalia
UNSPECIFIED
Henry, Marisa
UNSPECIFIED
Wynne, Maria
UNSPECIFIED
Santagostino, Sara F.
UNSPECIFIED
Brayton, Cory F.
UNSPECIFIED
Rasmussen, Lorna
UNSPECIFIED
Lisowski, Leszek
UNSPECIFIED
Tay, Szun S.
UNSPECIFIED
Harris, David C.
UNSPECIFIED
Bertram, John F.
UNSPECIFIED
Dowling, John P.
UNSPECIFIED
Bertolino, Patrick
UNSPECIFIED
Lai, Jack H.
UNSPECIFIED
Wu, Wengen
UNSPECIFIED
Bachovchin, William W.
UNSPECIFIED
Wong, Justin J.-L.
UNSPECIFIED
Gorrell, Mark D.
UNSPECIFIED
Shaban, Babak
UNSPECIFIED
Holmes, Edward C.
UNSPECIFIED
Jolly, Christopher J.
UNSPECIFIED
Monette, Sébastien
UNSPECIFIED
Weninger, Wolfgang
UNSPECIFIED
Last Modified: 03 Jan 2021 23:09
URI: https://eprints.centenary.org.au/id/eprint/485

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