Exosomal lncRNAs and cancer: connecting the missing links

Exosomal lncRNAs and cancer: connecting the missing links.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1093/bioinformatics%2Fbty527
Journal or Publication Title: Bioinformatics
Volume: 35
Number: 2
Page Range: pp. 352-360
Date: 2018
Divisions: Computational BioMedicine
Gene and Stem Cell Therapy
Depositing User: General Admin
Identification Number: 10.1093/bioinformatics/bty527
ISSN: 1367-4803
Date Deposited: 04 Jan 2021 23:34

Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Circulating exosomes are a source of stable RNAs including mRNAs, microRNAs and long non-coding RNAs (lncRNAs).

This review outlines the links between EVs, lncRNAs and cancer. We highlight communication networks involving the tumor microenvironment, the immune system and metastasis. We show examples supporting the value of exosomal lncRNAs as cancer biomarkers and therapeutic targets. We demonstrate how a system biology approach can be used to model cell–cell communication via exosomal lncRNAs and to simulate effects of therapeutic interventions. In addition, we introduce algorithms and bioinformatics resources for the discovery of tumor-specific lncRNAs and tools that are applied to determine exosome content and lncRNA function. Finally, this review provides a comprehensive collection and guide to databases for exosomal lncRNAs.

Naderi-Meshkin, Hojjat
Lai, Xin
Amirkhah, Raheleh
Vera, Julio
Rasko, John E J
Schmitz, Ulf
Wren, Jonathan
Last Modified: 04 Jan 2021 23:34
URI: https://eprints.centenary.org.au/id/eprint/466

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