COPD and the gut-lung axis: the therapeutic potential of fibre

COPD and the gut-lung axis: the therapeutic potential of fibre.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Journal of Thoracic Disease
Volume: 11
Number: S17
Page Range: S2173-S2180
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.21037/jtd.2019.10.40
ISSN: 20721439
Date Deposited: 04 Jan 2021 23:38

Current management strategies for chronic obstructive pulmonary disease (COPD) incorporate a step-wise, multidisciplinary approach to effectively manage patient symptoms and prevent disease progression. However, there has been limited advancement in therapies to address the underlying cause of COPD pathogenesis. Recent research has established the link between the lungs and the gut—the gut-lung axis -and the gut microbiome is a major component. The gut microbiome is likely perturbed in COPD, contributing to chronic inflammation. Diet is a readily modifiable factor and the diet of COPD patients is often deficient in nutrients such as fibre. The metabolism of dietary fibre by gut microbiomes produces anti-inflammatory short chain fatty acid (SCFAs), which could protect against inflammation in the lungs. By addressing the ‘fibre gap’ in the diet of COPD patients, this targeted dietary intervention may reduce inflammation, both systemically and in the airways, and value-add to the paradigm shift in respiratory medicine, from reactive to personalised and participatory medicine.

Vaughan, Annalicia
Frazer, Zoe A.
Hansbro, Philip M.
Yang, Ian A.
Last Modified: 04 Jan 2021 23:38

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