Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.cbi.2018.12.009
Journal or Publication Title: Chemico-Biological Interactions
Volume: 299
Page Range: pp. 168-178
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.cbi.2018.12.009
ISSN: 00092797
Date Deposited: 04 Jan 2021 23:39
Abstract:

Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic.

Creators:
Creators
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Dua, Kamal
UNSPECIFIED
Malyla, Vamshikrishna
UNSPECIFIED
Singhvi, Gautam
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Krishna, Rapalli Vamshi
UNSPECIFIED
Shukla, Shakti Dhar
UNSPECIFIED
Shastri, Madhur D.
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Maurya, Pawan Kumar
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Gulati, Monica
UNSPECIFIED
Hansbro, Nicole
UNSPECIFIED
Collet, Trudi
UNSPECIFIED
Awasthi, Rajendra
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Hsu, Alan
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Last Modified: 04 Jan 2021 23:39
URI: https://eprints.centenary.org.au/id/eprint/431

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