Mechanisms and Management of Asthma Exacerbations

Mechanisms and Management of Asthma Exacerbations.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: American Journal of Respiratory and Critical Care Medicine
Volume: 199
Number: 4
Page Range: pp. 423-432
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1164/rccm.201810-1931CI
ISSN: 1073-449X
Date Deposited: 04 Jan 2021 23:40

Acute asthma remains an important medical emergency, the most frequent cause of acute admissions in children and a major source of morbidity for adults with asthma. In all ages with asthma, the presence of exacerbations is an important defining characteristic of asthma severity. In this review, we assess the epidemiology of acute asthma, the triggers of acute exacerbations, and the mechanisms that underlie these exacerbations. We also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that effectively target this. Finally we review current management strategies of the exacerbations themselves.

Ramsahai, J. Michael
Hansbro, Philip M.
Wark, Peter A. B.
Last Modified: 04 Jan 2021 23:40

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