Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases

Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.cbi.2019.02.021
Journal or Publication Title: Chemico-Biological Interactions
Volume: 304
Page Range: pp. 10-19
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.cbi.2019.02.021
ISSN: 00092797
Date Deposited: 04 Jan 2021 23:43
Abstract:

Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so as to develop acquired immunity. Accounting to their involvement in pathogenesis, macrophages present a therapeutic target for the treatment of inflammatory respiratory diseases. This review focuses on novel drug delivery systems (NDDS) including nanoparticles, liposomes, dendrimers, microspheres etc that can target alveolar macrophage associated with inflammation, intracellular infection and lung cancer. The physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake. The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity. Further, the review also discuss about modified NDDS for specificity to the target and molecular targeting via anti-microbial peptides, kinases, NRF-2 and phosphodiesterase.

Creators:
Creators
Email
Mehta, Meenu
UNSPECIFIED
Deeksha
UNSPECIFIED
Sharma, Neha
UNSPECIFIED
Vyas, Manish
UNSPECIFIED
Khurana, Navneet
UNSPECIFIED
Maurya, Pawan Kumar
UNSPECIFIED
Singh, Harjeet
UNSPECIFIED
Andreoli de Jesus, Terezinha Pinto
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Collet, Trudi
UNSPECIFIED
Hansbro, Philip M
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Last Modified: 04 Jan 2021 23:43
URI: https://eprints.centenary.org.au/id/eprint/413

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