Molecular links between COPD and lung cancer: new targets for drug discovery?

Molecular links between COPD and lung cancer: new targets for drug discovery?

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://doi.org/10.1080/14728222.2019.1615884
Journal or Publication Title: Expert Opinion on Therapeutic Targets
Volume: 23
Number: 6
Page Range: pp. 539-553
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1080/14728222.2019.1615884
ISSN: 1472-8222
Date Deposited: 04 Jan 2021 23:45
Abstract:

Introduction: COPD and lung cancer are leading causes of morbidity and mortality worldwide, and they share a common environmental risk factor in cigarette smoke exposure and a genetic predisposition represented by their incidence in only a fraction of smokers. This reflects the ability of cigarette smoke to induce an inflammatory response in the airways of susceptible smokers. Moreover, COPD could be a driving factor in lung cancer, by increasing oxidative stress and the resulting DNA damage and repression of the DNA repair mechanisms, chronic exposure to pro-inflammatory cytokines, repression of innate immunity and increased cellular proliferation.

Areas covered: We have focused our review on the potential pathogenic molecular links between tobacco smoking-related COPD and lung cancer and the potential molecular targets for new drug development by understanding the common signaling pathways involved in COPD and lung cancer.

Expert commentary: Research in this field is mostly limited to animal models or small clinical trials. Large clinical trials are needed but mostly combined models of COPD and lung cancer are necessary to investigate the processes caused by chronic inflammation, including genetic and epigenetic alteration, and the expression of inflammatory mediators that link COPD and lung cancer, to identify new molecular therapeutic targets.

Creators:
Creators
Email
Caramori, Gaetano
UNSPECIFIED
Ruggeri, Paolo
UNSPECIFIED
Mumby, Sharon
UNSPECIFIED
Ieni, Antonio
UNSPECIFIED
Lo Bello, Federica
UNSPECIFIED
Chimankar, Vrushali
UNSPECIFIED
Donovan, Chantal
UNSPECIFIED
Andò, Filippo
UNSPECIFIED
Nucera, Francesco
UNSPECIFIED
Coppolino, Irene
UNSPECIFIED
Tuccari, Giovanni
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Adcock, Ian M.
UNSPECIFIED
Last Modified: 04 Jan 2021 23:45
URI: https://eprints.centenary.org.au/id/eprint/409

Actions (login required)

View Item View Item