Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.cbi.2019.05.028
Journal or Publication Title: Chemico-Biological Interactions
Volume: 308
Page Range: pp. 206-215
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.cbi.2019.05.028
ISSN: 00092797
Date Deposited: 04 Jan 2021 23:47
Abstract:

Oligonucleotide-based therapies are advanced novel interventions used in the management of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). These agents primarily act by gene silencing or RNA interference. Better methodologies and techniques are the need of the hour that can deliver these agents to tissues and cells in a target specific manner by which their maximum potential can be reached in the management of chronic inflammatory diseases. Nanoparticles play an important role in the target-specific delivery of drugs. In addition, oligonucleotides also are extensively used for gene transfer in the form of polymeric, liposomal and inorganic carrier materials. Therefore, the current review focuses on various novel dosage forms like nanoparticles, liposomes that can be used efficiently for the delivery of various oligonucleotides such as siRNA and miRNA. We also discuss the future perspectives and targets for oligonucleotides in the management of respiratory diseases.

Creators:
Creators
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Mehta, Meenu
UNSPECIFIED
Deeksha
UNSPECIFIED
Tewari, Devesh
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Awasthi, Rajendra
UNSPECIFIED
Singh, Harjeet
UNSPECIFIED
Pandey, Parijat
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Collet, Trudi
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Kumar, S Rajesh
UNSPECIFIED
Thangavelu, Lakshmi
UNSPECIFIED
Negi, Poonam
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Last Modified: 04 Jan 2021 23:47
URI: https://eprints.centenary.org.au/id/eprint/400

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