The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.3390/cells8080929
Journal or Publication Title: Cells
Volume: 8
Number: 8
Page Range: p. 929
Date: 2019
Divisions: Computational BioMedicine
Depositing User: General Admin
Identification Number: 10.3390/cells8080929
ISSN: 2073-4409
Date Deposited: 04 Jan 2021 23:49
Abstract:

Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-specific epigenetic variations escorting this process include chromatin remodelling, histone modifications and aberrant DNA methylation, which influence gene expression, alternative splicing and function of non-coding RNA. In this review, we first highlight epigenetic modulators, modifiers and mediators in CRC, then we elaborate on causes and consequences of epigenetic alterations in CRC pathogenesis alongside an appraisal of the complex feedback mechanisms realized through alternative splicing and non-coding RNA regulation. An emphasis in our review is put on how this intricate network of epigenetic and post-transcriptional gene regulation evolves during the initiation, progression and metastasis formation in CRC.

Creators:
Creators
Email
Amirkhah, Raheleh
UNSPECIFIED
Naderi-Meshkin, Hojjat
UNSPECIFIED
Shah, Jaynish
UNSPECIFIED
Dunne, Philip
UNSPECIFIED
Schmitz, Ulf
UNSPECIFIED
Last Modified: 04 Jan 2021 23:49
URI: https://eprints.centenary.org.au/id/eprint/394

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