Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease

Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1002/jcp.28482
Journal or Publication Title: Journal of Cellular Physiology
Volume: 234
Number: 10
Page Range: pp. 16703-16723
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1002/jcp.28482
ISSN: 0021-9541
Date Deposited: 04 Jan 2021 23:49
Abstract:

Chronic obstructive pulmonary disease accounts as the leading cause of mortality worldwide prominently affected by genetic and environmental factors. The disease is characterized by persistent coughing, breathlessness airways inflammation followed by a decrease in forced expiratory volume1 and exacerbations, which affect the quality of life. Determination of genetic, epigenetic, and oxidant biomarkers to evaluate the progression of disease has proved complicated and challenging. Approaches including exome sequencing, genome‐wide association studies, linkage studies, and inheritance and segregation studies played a crucial role in the identification of genes, their pathways and variation in genes. This review highlights multiple approaches for biomarker and gene identification, which can be used for differential diagnosis along with the genome editing tools to study genes associated with the development of disease and models their function. Further, we have discussed the approaches to rectify the abnormal gene functioning of respiratory tissues and various novel gene editing techniques like Zinc finger nucleases (ZFN), transcription activator‐like effector nucleases (TALEN), and clustered regulatory interspaced short palindromic repeats/CRISPR‐associated protein 9 (CRISPR/Cas9).

Creators:
Creators
Email
Wadhwa, Ridhima
UNSPECIFIED
Aggarwal, Taru
UNSPECIFIED
Malyla, Vamshikrishna
UNSPECIFIED
Kumar, Nitesh
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Gulati, Monica
UNSPECIFIED
Maurya, Pawan Kumar
UNSPECIFIED
Collet, Trudi
UNSPECIFIED
Hansbro, Philip Michael
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 04 Jan 2021 23:49
URI: https://eprints.centenary.org.au/id/eprint/390

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