The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy

The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Frontiers in Oncology
Volume: 9
Date: 2019
Divisions: Gene and Stem Cell Therapy
Depositing User: General Admin
Identification Number: 10.3389/fonc.2019.01366
ISSN: 2234-943X
Date Deposited: 04 Jan 2021 23:52

Although mesothelioma is the consequence of a protracted immune response to asbestos fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches show less convincing results as compared to those seen in melanoma and non-small cell lung cancer. The immune suppressive microenvironment in mesothelioma is likely contributing to this therapy resistance. Therefore, it is important to explore the characteristics of the tumor microenvironment for explanations for this recalcitrant behavior. This review describes the stromal, cytokine, metabolic, and cellular milieu of mesothelioma, and attempts to make connection with the outcome of immunotherapy trials.

Chu, Gerard J.
van Zandwijk, Nico
Rasko, John E. J.
Last Modified: 04 Jan 2021 23:52

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