Epithelial–mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics

Epithelial–mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics.

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://doi.org/10.2147/COPD.S208428
Journal or Publication Title: International Journal of Chronic Obstructive Pulmonary Disease
Volume: Volume
Page Range: pp. 1603-1610
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.2147/COPD.S208428
ISSN: 1178-2005
Date Deposited: 21 Dec 2020 00:39
Abstract:

COPD is a common and highly destructive disease with huge impacts on people and health services throughout the world. It is mainly caused by cigarette smoking though environmental pollution is also significant. There are no current treatments that affect the overall course of COPD; current drugs focus on symptomatic relief and to some extent reducing exacerbation rates. There is an urgent need for in-depth studies of the fundamental pathogenic mechanisms that underpin COPD. This is vital, given the fact that nearly 40%-60% of the small airway and alveolar damage occurs in COPD well before the first measurable changes in lung function are detected. These individuals are also at a high risk of lung cancer. Current COPD research is mostly centered around late disease and/or innate immune activation within the airway lumen, but the actual damage to the airway wall has early onset. COPD is the end result of complex mechanisms, possibly triggered through initial epithelial activation. To change the disease trajectory, it is crucial to understand the mechanisms in the epithelium that are switched on early in smokers. One such mechanism we believe is the process of epithelial to mesenchymal transition. This article highlights the importance of this profound epithelial cell plasticity in COPD and also its regulation. We consider that understanding early changes in COPD will open new windows for therapy.

Keywords: EGFR; HuR; MMP; TGFβ; cancer; epithelial-to-mesenchymal transition, EMT; fibrosis; inflammation.

Creators:
Creators
Email
Eapen, Mathew Suji
UNSPECIFIED
Sharma, Pawan
UNSPECIFIED
Gaikwad, Archana Vijay
UNSPECIFIED
Lu, Wenying
UNSPECIFIED
Myers, Stephen
UNSPECIFIED
Hansbro, Philip M
UNSPECIFIED
Sohal, Sukhwinder Singh
UNSPECIFIED
Last Modified: 21 Dec 2020 00:39
URI: https://eprints.centenary.org.au/id/eprint/349

Actions (login required)

View Item View Item