Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease

Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1002/JLB.3AB0518-178R
Journal or Publication Title: Journal of Leukocyte Biology
Volume: 105
Number: 1
Page Range: pp. 143-150
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1002/JLB.3AB0518-178R
ISSN: 0741-5400
Date Deposited: 21 Dec 2020 03:12
Abstract:

Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized by both innate and adaptive immune responses; however, their specific roles in the pathogenesis of COPD are unclear. Therefore, we investigated the roles of T and B lymphocytes and group 2 innate lymphoid cells (ILC2s) in airway inflammation and remodelling, and lung function in an experimental model of COPD using mice that specifically lack these cells (Rag1-/- and Rorafl/fl Il7rCre [ILC2-deficient] mice). Wild-type (WT) C57BL/6 mice, Rag1-/- , and Rorafl/fl Il7rCre mice were exposed to cigarette smoke (CS; 12 cigarettes twice a day, 5 days a week) for up to 12 weeks, and airway inflammation, airway remodelling (collagen deposition and alveolar enlargement), and lung function were assessed. WT, Rag1-/- , and ILC2-deficient mice exposed to CS had similar levels of airway inflammation and impaired lung function. CS exposure increased small airway collagen deposition in WT mice. Rag1-/- normal air- and CS-exposed mice had significantly increased collagen deposition compared to similarly exposed WT mice, which was associated with increases in IL-33, IL-13, and ILC2 numbers. CS-exposed Rorafl/fl Il7rCre mice were protected from emphysema, but had increased IL-33/IL-13 expression and collagen deposition compared to WT CS-exposed mice. T/B lymphocytes and ILC2s play roles in airway collagen deposition/fibrosis, but not inflammation, in experimental COPD.

Keywords: COPD; ILC2s; T cells; emphysema; inflammation; remodelling.

©2018 Society for Leukocyte Biology.

Creators:
Creators
Email
Donovan, Chantal
UNSPECIFIED
Starkey, Malcolm R.
UNSPECIFIED
Kim, Richard Y.
UNSPECIFIED
Rana, Batika M. J.
UNSPECIFIED
Barlow, Jillian L.
UNSPECIFIED
Jones, Bernadette
UNSPECIFIED
Haw, Tatt Jhong
UNSPECIFIED
Mono Nair, Prema
UNSPECIFIED
Budden, Kurtis
UNSPECIFIED
Cameron, Guy J.M.
UNSPECIFIED
Horvat, Jay C.
UNSPECIFIED
Wark, Peter A.
UNSPECIFIED
Foster, Paul S.
UNSPECIFIED
McKenzie, Andrew N. J.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Last Modified: 21 Dec 2020 03:12
URI: https://eprints.centenary.org.au/id/eprint/330

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