Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia

Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia.

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://doi.org/10.1111/imcb.12197
Journal or Publication Title: Immunology and Cell Biology
Volume: 97
Number: 1
Page Range: pp. 29-38
Date: 2018
Divisions: Immune Imaging
Depositing User: General Admin
Identification Number: 10.1111/imcb.12197
ISSN: 08189641
Date Deposited: 21 Dec 2020 05:51
Abstract:

BPSM1 (Bone phenotype spontaneous mutant 1) mice develop severe polyarthritis and heart valve disease as a result of a spontaneous mutation in the Tnf gene. In these mice, the insertion of a retrotransposon in the 3' untranslated region of Tnf causes a large increase in the expression of the cytokine. We have found that these mice also develop inducible bronchus-associated lymphoid tissue (iBALT), as well as nodular lymphoid hyperplasia (NLH) in the bone marrow. Loss of TNFR1 prevents the development of both types of follicles, but deficiency of TNFR1 in the hematopoietic compartment only prevents the iBALT and not the NLH phenotype. We show that the development of arthritis and heart valve disease does not depend on the presence of the tertiary lymphoid tissues. Interestingly, while loss of IL-17 or IL-23 limits iBALT and NLH development to some extent, it has no effect on polyarthritis or heart valve disease in BPSM1 mice.

Keywords: Arthritis; BPSM1; IL-17; IL-23; NLH; TNF; heart valve disease; iBALT; nodular lymphoid hyperplasia; tertiary lymphoid organs, bronchus-associated.

© 2018 The Authors Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc.

Creators:
Creators
Email
Seillet, Cyril
UNSPECIFIED
Carr, Elysa
UNSPECIFIED
Lacey, Derek
UNSPECIFIED
Stutz, Michael D
UNSPECIFIED
Pellegrini, Marc
UNSPECIFIED
Whitehead, Lachlan
UNSPECIFIED
Rimes, Joel
UNSPECIFIED
Hawkins, Edwin D
UNSPECIFIED
Roediger, Ben
UNSPECIFIED
Belz, Gabrielle T
UNSPECIFIED
Bouillet, Philippe
UNSPECIFIED
Last Modified: 21 Dec 2020 05:51
URI: https://eprints.centenary.org.au/id/eprint/322

Actions (login required)

View Item View Item