Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia

Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Immunology and Cell Biology
Volume: 97
Number: 1
Page Range: pp. 29-38
Date: 2018
Divisions: Immune Imaging
Depositing User: General Admin
Identification Number: 10.1111/imcb.12197
ISSN: 08189641
Date Deposited: 21 Dec 2020 05:51

BPSM1 (Bone phenotype spontaneous mutant 1) mice develop severe polyarthritis and heart valve disease as a result of a spontaneous mutation in the Tnf gene. In these mice, the insertion of a retrotransposon in the 3' untranslated region of Tnf causes a large increase in the expression of the cytokine. We have found that these mice also develop inducible bronchus-associated lymphoid tissue (iBALT), as well as nodular lymphoid hyperplasia (NLH) in the bone marrow. Loss of TNFR1 prevents the development of both types of follicles, but deficiency of TNFR1 in the hematopoietic compartment only prevents the iBALT and not the NLH phenotype. We show that the development of arthritis and heart valve disease does not depend on the presence of the tertiary lymphoid tissues. Interestingly, while loss of IL-17 or IL-23 limits iBALT and NLH development to some extent, it has no effect on polyarthritis or heart valve disease in BPSM1 mice.

Keywords: Arthritis; BPSM1; IL-17; IL-23; NLH; TNF; heart valve disease; iBALT; nodular lymphoid hyperplasia; tertiary lymphoid organs, bronchus-associated.

© 2018 The Authors Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc.

Seillet, Cyril
Carr, Elysa
Lacey, Derek
Stutz, Michael D
Pellegrini, Marc
Whitehead, Lachlan
Rimes, Joel
Hawkins, Edwin D
Roediger, Ben
Belz, Gabrielle T
Bouillet, Philippe
Last Modified: 21 Dec 2020 05:51

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