Fibroblast activation protein in liver fibrosis

Fibroblast activation protein in liver fibrosis.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Frontiers in Bioscience
Volume: 24
Number: 1
Page Range: pp. 1-17
Date: 2019
Divisions: Liver Enzymes in Metabolism and Inflammation
Depositing User: General Admin
Identification Number: 10.2741/4706
ISSN: 10939946
Date Deposited: 21 Dec 2020 00:45

Fibroblast activation protein (FAP) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family. Other related genes in this family of enzyme include DPP4, 8 and 9. The FAP serine protease has the rare property of both dipeptidyl peptidase and endopeptidase activities capable of cleaving the post-proline bond at two or more residues from the N-terminus. FAP is involved in a variety of biological processes but its expression in healthy tissues is low. In contrast, FAP is significantly elevated in pathological conditions such as at sites of tissue remodelling and repair. Its differential pattern of expression in diseases supports the emerging concept for FAP as a potential disease biomarker as well as a useful therapeutic target for drug intervention. This review summarizes the current knowledge of FAP, particularly its diagnostic and pathological significance in liver fibrosis.

Gorrell, Mark Douglas
Last Modified: 21 Dec 2020 00:45

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