Enhancing tristetraprolin activity reduces the severity of cigarette smoke‐induced experimental chronic obstructive pulmonary disease

Enhancing tristetraprolin activity reduces the severity of cigarette smoke‐induced experimental chronic obstructive pulmonary disease.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1002/cti2.1084
Journal or Publication Title: Clinical & Translational Immunology
Volume: 8
Number: 10
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1002/cti2.1084
ISSN: 2050-0068
Date Deposited: 22 Dec 2020 03:01
Abstract:

Chronic obstructive pulmonary disease (COPD) is a progressive disease that causes significant mortality and morbidity worldwide and is primarily caused by the inhalation of cigarette smoke (CS). Lack of effective treatments for COPD means there is an urgent need to identify new therapeutic strategies for the underlying mechanisms of pathogenesis. Tristetraprolin (TTP) encoded by the Zfp36 gene is an anti‐inflammatory protein that induces mRNA decay, especially of transcripts encoding inflammatory cytokines, including those implicated in COPD.

Creators:
Creators
Email
Nair, Prema M
UNSPECIFIED
Starkey, Malcolm R
UNSPECIFIED
Haw, Tatt Jhong
UNSPECIFIED
Liu, Gang
UNSPECIFIED
Collison, Adam M
UNSPECIFIED
Mattes, Joerg
UNSPECIFIED
Wark, Peter A.
UNSPECIFIED
Morris, Jonathan C
UNSPECIFIED
Verrills, Nikki M
UNSPECIFIED
Clark, Andrew R
UNSPECIFIED
Ammit, Alaina J
UNSPECIFIED
Hansbro, Philip M
UNSPECIFIED
Last Modified: 22 Dec 2020 03:01
URI: https://eprints.centenary.org.au/id/eprint/309

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