Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy.
Full text not available from this repository.| Item Type: | Article |
|---|---|
| Status: | Published |
| Official URL: | https://doi.org/10.1016/j.ccell.2019.01.003 |
| Journal or Publication Title: | Cancer Cell |
| Volume: | 35 |
| Number: | 2 |
| Page Range: | 238-255.e6 |
| Date: | 2019 |
| Divisions: | Human Viral and Cancer Immunology |
| Depositing User: | General Admin |
| Identification Number: | 10.1016/j.ccell.2019.01.003 |
| ISSN: | 15356108 |
| Date Deposited: | 17 Dec 2020 02:51 |
| Abstract: | Cancer immunotherapies provide survival benefits in responding patients, but many patients fail to respond. Identifying the biology of treatment response and resistance are a priority to optimize drug selection and improve patient outcomes. We performed transcriptomic and immune profiling on 158 tumor biopsies from melanoma patients treated with anti-PD-1 monotherapy (n = 63) or combined anti-PD-1 and anti-CTLA-4 (n = 57). These data identified activated T cell signatures and T cell populations in responders to both treatments. Further mass cytometry analysis identified an EOMES+CD69+CD45RO+ effector memory T cell phenotype that was significantly more abundant in responders to combined immunotherapy compared with non-responders (n = 18). The gene expression profile of this population was associated with longer progression-free survival in patients treated with single agent and greater tumor shrinkage in both treatments. Keywords: EOMES; RNA-seq; anti-CTLA-4; anti-PD-1; combination therapy; immune checkpoint inhibitors; immunotherapy; melanoma; predictive biomarkers; resistance mechanisms. Copyright © 2019 Elsevier Inc. All rights reserved. |
| Creators: | Creators Email Gide, Tuba N. UNSPECIFIED Quek, Camelia UNSPECIFIED Menzies, Alexander M. UNSPECIFIED Tasker, Annie T. UNSPECIFIED Shang, Ping UNSPECIFIED Holst, Jeff UNSPECIFIED Madore, Jason UNSPECIFIED Lim, Su Yin UNSPECIFIED Velickovic, Rebecca UNSPECIFIED Wongchenko, Matthew UNSPECIFIED Yan, Yibing UNSPECIFIED Lo, Serigne UNSPECIFIED Carlino, Matteo S. UNSPECIFIED Guminski, Alexander UNSPECIFIED Saw, Robyn P.M. UNSPECIFIED Pang, Angel UNSPECIFIED McGuire, Helen M. UNSPECIFIED Palendira, Umaimainthan UNSPECIFIED Thompson, John F. UNSPECIFIED Rizos, Helen UNSPECIFIED Silva, Ines Pires da UNSPECIFIED Batten, Marcel UNSPECIFIED Scolyer, Richard A. UNSPECIFIED Long, Georgina V. UNSPECIFIED Wilmott, James S. UNSPECIFIED |
| Last Modified: | 17 Dec 2020 02:51 |
| URI: | https://eprints.centenary.org.au/id/eprint/282 |
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