APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?

APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://doi.org/10.1007/s12072-018-9915-5
Journal or Publication Title: Hepatology International
Volume: 13
Number: 2
Page Range: pp. 103-109
Date: 2019
Divisions: Liver Injury and Cancer
Depositing User: General Admin
Identification Number: 10.1007/s12072-018-9915-5
ISSN: 1936-0533
Date Deposited: 17 Dec 2020 03:17
Abstract:

Chronic hepatitis C virus (HCV) infection is common among patients with chronic kidney disease (CKD) and those on hemodialysis due to nosocomial infections and past blood transfusions. While a majority of HCV-infected patients with end-stage renal disease are asymptomatic, some may ultimately experience decompensated liver diseases and hepatocellular carcinoma. Administration of a combination of elbasvir/grazoprevir for 12 weeks leads to high sustained virologic response (SVR) rates in patients with HCV genotypes (GTs) 1a, 1b or 4 and stage 4 or 5 CKD. Furthermore, a combination of glecaprevir/pibrentasvir for 8-16 weeks also results in high SVR rates in patients with all HCV GTs and stage 4 or 5 CKD. However, these regimens are contraindicated in the presence of advanced decompensated cirrhosis. Although sofosbuvir and/or ribavirin are not generally recommended for HCV-infected patients with severe renal impairment, sofosbuvir-based regimens may be appropriate for those with mild renal impairment. To eliminate HCV worldwide, HCV-infected patients with renal impairment should be treated with interferon-free therapies.

Keywords: DAA; Guideline; HCV; Hemodialysis; Renal impairment; SVR.

Creators:
Creators
Email
Kanda, Tatsuo
UNSPECIFIED
Lau, George K. K.
UNSPECIFIED
Wei, Lai
UNSPECIFIED
Moriyama, Mitsuhiko
UNSPECIFIED
Yu, Ming-Lung
UNSPECIFIED
Chuang, Wang-Long
UNSPECIFIED
Ibrahim, Alaaeldin
UNSPECIFIED
Lesmana, Cosmas Rinaldi Adithya
UNSPECIFIED
Sollano, Jose
UNSPECIFIED
Kumar, Manoj
UNSPECIFIED
Jindal, Ankur
UNSPECIFIED
Sharma, Barjesh Chander
UNSPECIFIED
Hamid, Saeed S.
UNSPECIFIED
Dokmeci, A. Kadir
UNSPECIFIED
Mamun-Al-Mahtab
UNSPECIFIED
McCaughan, Geofferey W.
UNSPECIFIED
Wasim, Jafri
UNSPECIFIED
Crawford, Darrell H. G.
UNSPECIFIED
Kao, Jia-Horng
UNSPECIFIED
Yokosuka, Osamu
UNSPECIFIED
Sarin, Shiv Kumar
UNSPECIFIED
Omata, Masao
UNSPECIFIED
Last Modified: 17 Dec 2020 03:17
URI: https://eprints.centenary.org.au/id/eprint/267

Actions (login required)

View Item View Item