Multiple receptors converge on H2‐Q10 to regulate NK and γδT‐cell development

Multiple receptors converge on H2‐Q10 to regulate NK and γδT‐cell development.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Immunology & Cell Biology
Volume: 97
Number: 3
Page Range: pp. 326-339
Date: 2019
Divisions: Liver Immunology
Depositing User: General Admin
Identification Number: 10.1111/imcb.12222
ISSN: 0818-9641
Date Deposited: 17 Dec 2020 03:23

Class Ib major histocompatibility complex (MHC) is an extended family of molecules, which demonstrate tissue-specific expression and presentation of monomorphic antigens. These characteristics tend to imbue class Ib MHC with unique functions. H2-Q10 is potentially one such molecule that is overexpressed in the liver but its immunological function is not known. We have previously shown that H2-Q10 is a ligand for the natural killer cell receptor Ly49C and now, using H2-Q10-deficient mice, we demonstrate that H2-Q10 can also stabilize the expression of Qa-1b. In the absence of H2-Q10, the development and maturation of conventional hepatic natural killer cells is disrupted. We also provide evidence that H2-Q10 is a new high affinity ligand for CD8αα and controls the development of liver-resident CD8αα γδT cells. These data demonstrate that H2-Q10 has multiple roles in the development of immune subsets and identify an overlap of recognition within the class Ib MHC that is likely to be relevant to the regulation of immunity.

Keywords: CD8αα; natural killer cells; non-classical MHC; γδT cells.

© 2018 Australasian Society for Immunology Inc.

Goodall, Katharine J
Nguyen, Angela
Matsumoto, Aya
McMullen, Julie R
Eckle, Sidonia B
Bertolino, Patrick
Sullivan, Lucy C
Andrews, Daniel M
Last Modified: 17 Dec 2020 03:23

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