Animal models for hepatocellular carcinoma

Animal models for hepatocellular carcinoma.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume: 1865
Number: 5
Page Range: pp. 993-1002
Date: 2019
Divisions: Liver Enzymes in Metabolism and Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.bbadis.2018.08.009
ISSN: 09254439
Date Deposited: 21 Dec 2020 22:44

Hepatocellular carcinoma (HCC) represents ~90% of all cases of primary liver cancer and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Establishing appropriate animal models for HCC is required for basic and translational studies, especially the models that can recapitulate one of the human disease settings. Current animal models can be categorized as chemically-induced, genetically-engineered, xenograft, or a combination of these with each other or with a metabolic insult. A single approach to resemble human HCC in animals is not sufficient. Combining pathogenic insults in animal models may more realistically recapitulate the multiple etiologic agents occurring in humans. Combining chemical injury with metabolic disorder or alcohol consumption in mice reduces the time taken to hepatocarcinogenesis. Genetically-engineering weak activation of HCC-promoting pathways combined with disease-specific injury models will possibly mimic the pathophysiology of human HCC in distinct clinical settings.

Keywords: Animal model; Chemical; Genetically engineered mouse; Hepatocellular carcinoma; Xenograft.

Copyright © 2018 Elsevier B.V. All rights reserved.

Zhang, Hui Emma
Henderson, James M.
Gorrell, Mark D.
Last Modified: 21 Dec 2020 22:44

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