Commonly integrated epigenetic modifications of differentially expressed genes lead to adaptive resistance in cancer

Commonly integrated epigenetic modifications of differentially expressed genes lead to adaptive resistance in cancer.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.2217/epi-2018-0173
Journal or Publication Title: Epigenomics
Volume: 11
Number: 7
Page Range: pp. 732-737
Date: 2019
Divisions: Melanoma Oncology and Immunology
Depositing User: General Admin
Identification Number: 10.2217/epi-2018-0173
ISSN: 1750-1911
Date Deposited: 21 Dec 2020 22:48
Abstract:

Aim: To investigate the integrated epigenetic regulation of acquired drug resistance in cancer. Materials & methods: Our gene expression data of five induced drug-tolerant cell models, one resistant cell line and one publicly available drug-resistant dataset were integrated to identify common differentially expressed genes and pathways. ChIP-seq and DNA methylation by HM450K beadchip were used to study the epigenetic profile of differential expressed genes.

Results & conclusion: Integrated transcriptomic analysis identified a common 'viral mimicry' related gene signature in induced drug-tolerant cells and the resistant state. Analysis of the epigenetic regulation revealed a common set of down-regulated genes, which are marked and regulated by a concomitant loss of H3K4me3, gain of H3K9me3 and increment of regional DNA methylation levels associated with tumor suppressor genes and apoptotic signaling.

Keywords: DNA methylation; IDTC; LINE-1; adaptive resistance; differentially expressed genes; epigenetic remodeling; induced drug-tolerant cell; repressive histone marks; viral mimicry.

Creators:
Creators
Email
Emran, Abdullah Al
UNSPECIFIED
Marzese, Diego M
UNSPECIFIED
Menon, Dinoop R
UNSPECIFIED
Hammerlindl, Heinz
UNSPECIFIED
Ahmed, Farzana
UNSPECIFIED
Richtig, Erika
UNSPECIFIED
Duijf, Pascal
UNSPECIFIED
Hoon, Dave SB
UNSPECIFIED
Schaider, Helmut
UNSPECIFIED
Last Modified: 21 Dec 2020 22:48
URI: https://eprints.centenary.org.au/id/eprint/222

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