Microbiome-focused asthma management strategies

Microbiome-focused asthma management strategies.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.coph.2019.06.003
Journal or Publication Title: Current Opinion in Pharmacology
Volume: 46
Page Range: pp. 143-149
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.coph.2019.06.003
ISSN: 14714892
Date Deposited: 21 Dec 2020 22:56
Abstract:

Asthma is a common, heterogeneous and serious disease with high prevalence globally. Poorly controlled, steroid-resistant asthma is particularly important as there are no effective therapies and it exerts substantial healthcare and societal burden. The role of microbiomes, particularly in chronic diseases has generated considerable interest in recent times. Existing evidence clearly demonstrates an association between asthma initiation and the microbiome, both respiratory and gastro-intestinal, although its' roles are poorly understood when assessing the asthma progression or heterogeneity (i.e. phenotypes/endotypes) across different geographical locations. Moreover, modulating microbiomes could be preventive and/or therapeutic in patients with asthma warrants urgent attention. Here, we review recent advances in assessing the role of microbiomes in asthma and present the challenges associated with the potential therapeutic utility of modifying microbiomes in management.

Copyright © 2019 Elsevier Ltd. All rights reserved.

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Shukla, Shakti D
UNSPECIFIED
Shastri, Madhur D
UNSPECIFIED
Chong, Wai Chin
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Budden, Kurtis F
UNSPECIFIED
Mahmood, Malik Quasir
UNSPECIFIED
Hansbro, Nicole G
UNSPECIFIED
Keely, Simon
UNSPECIFIED
Eri, Rajaraman
UNSPECIFIED
Patel, Rahul P
UNSPECIFIED
Peterson, Gregory M
UNSPECIFIED
Hansbro, Philip M
UNSPECIFIED
Last Modified: 21 Dec 2020 22:56
URI: https://eprints.centenary.org.au/id/eprint/202

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