Perceptions of genetic variant reclassification in patients with inherited cardiac disease

Perceptions of genetic variant reclassification in patients with inherited cardiac disease.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: European Journal of Human Genetics
Volume: 27
Number: 7
Page Range: pp. 1134-1142
Date: 2019
Divisions: Cardio Genomics
Molecular Cardiology
Depositing User: General Admin
Identification Number: 10.1038/s41431-019-0377-6
ISSN: 1018-4813
Date Deposited: 21 Dec 2020 22:59

Interpretation of sequence variants is an ongoing challenge and new approaches aim to increase stringency. The reclassification of variants has the potential to alter medical management and elicit psychosocial consequences for patients. The perspective of patients with an inherited cardiac disease and a clinically significant variant reclassification was explored through semi-structured phone interviews. Participants were recruited from two specialized multidisciplinary centers in Canada and Australia. Qualitative analysis was performed through a thematic analysis approach. Fifteen participants were interviewed, including 9 (60%) with an inherited cardiomyopathy and 6 (40%) with an inherited arrhythmia syndrome. Six (40%) patients had a classification upgrade, while 9 (60%) had a downgrade. Four major themes emerged: (1) reactions towards the reclassified variant; (2) impact on decision-making; (3) perception of the reclassification process; and (4) improvement of the reclassification process. Many patients adjusted to the reclassification, however some misunderstood the implications, impacting their responses and decision-making. In conclusion, careful discussion with patients about uncertainty and the potential for reclassification are crucial to ensure a deeper understanding of the outcome of genetic testing and impact on families.

Wong, Eugene K.
Bartels, Kirsten
Hathaway, Julie
Burns, Charlotte
Yeates, Laura
Semsarian, Christopher
Krahn, Andrew D.
Virani, Alice
Ingles, Jodie
Last Modified: 21 Dec 2020 22:59

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