IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis

IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1183/13993003.00174-2018
Journal or Publication Title: European Respiratory Journal
Volume: 54
Number: 1
Page Range: p. 1800174
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1183/13993003.00174-2018
ISSN: 0903-1936
Date Deposited: 21 Dec 2020 23:01
Abstract:

Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and death globally. The lack of effective treatments results from an incomplete understanding of the underlying mechanisms driving COPD pathogenesis.Interleukin (IL)-22 has been implicated in airway inflammation and is increased in COPD patients. However, its roles in the pathogenesis of COPD is poorly understood. Here, we investigated the role of IL-22 in human COPD and in cigarette smoke (CS)-induced experimental COPD.IL-22 and IL-22 receptor mRNA expression and protein levels were increased in COPD patients compared to healthy smoking or non-smoking controls. IL-22 and IL-22 receptor levels were increased in the lungs of mice with experimental COPD compared to controls and the cellular source of IL-22 included CD4+ T-helper cells, γδ T-cells, natural killer T-cells and group 3 innate lymphoid cells. CS-induced pulmonary neutrophils were reduced in IL-22-deficient (Il22 -/-) mice. CS-induced airway remodelling and emphysema-like alveolar enlargement did not occur in Il22 -/- mice. Il22 -/- mice had improved lung function in terms of airway resistance, total lung capacity, inspiratory capacity, forced vital capacity and compliance.These data highlight important roles for IL-22 and its receptors in human COPD and CS-induced experimental COPD.

Creators:
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Starkey, Malcolm R.
UNSPECIFIED
Plank, Maximilian W.
UNSPECIFIED
Casolari, Paolo
UNSPECIFIED
Papi, Alberto
UNSPECIFIED
Pavlidis, Stelios
UNSPECIFIED
Guo, Yike
UNSPECIFIED
Cameron, Guy J.M.
UNSPECIFIED
Haw, Tatt Jhong
UNSPECIFIED
Tam, Anthony
UNSPECIFIED
Obiedat, Ma'en
UNSPECIFIED
Donovan, Chantal
UNSPECIFIED
Hansbro, Nicole G.
UNSPECIFIED
Nguyen, Duc H.
UNSPECIFIED
Nair, Prema Mono
UNSPECIFIED
Kim, Richard Y.
UNSPECIFIED
Horvat, Jay C.
UNSPECIFIED
Kaiko, Gerard E.
UNSPECIFIED
Durum, Scott K.
UNSPECIFIED
Wark, Peter A.
UNSPECIFIED
Sin, Don D.
UNSPECIFIED
Caramori, Gaetano
UNSPECIFIED
Adcock, Ian M.
UNSPECIFIED
Foster, Paul S.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Last Modified: 21 Dec 2020 23:01
URI: https://eprints.centenary.org.au/id/eprint/189

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