The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1002/ddr.21571
Journal or Publication Title: Drug Development Research
Volume: 80
Number: 6
Page Range: pp. 714-730
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1002/ddr.21571
ISSN: 0272-4391
Date Deposited: 21 Dec 2020 23:03
Abstract:

Lung diseases are the leading cause of mortality worldwide. The currently available therapies are not sufficient, leading to the urgent need for new therapies with sustained anti-inflammatory effects. Small/short or silencing interfering RNA (siRNA) has potential therapeutic implications through post-transcriptional downregulation of the target gene expression. siRNA is essential in gene regulation, so is more favorable over other gene therapies due to its small size, high specificity, potency, and no or low immune response. In chronic respiratory diseases, local and targeted delivery of siRNA is achieved via inhalation. The effectual delivery can be attained by the generation of aerosols via inhalers and nebulizers, which overcomes anatomical barriers, alveolar macrophage clearance and mucociliary clearance. In this review, we discuss the different siRNA nanocarrier systems for chronic respiratory diseases, for safe and effective delivery. siRNA mediated pro-inflammatory gene or miRNA targeting approach can be a useful approach in combating chronic respiratory inflammatory conditions and thus providing sustained drug delivery, reduced therapeutic dose, and improved patient compliance. This review will be of high relevance to the formulation, biological and translational scientists working in the area of respiratory diseases.

Keywords: RNA interference; delivery systems; nanocarriers; pulmonary; siRNA.

© 2019 Wiley Periodicals, Inc.

Creators:
Creators
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Dua, Kamal
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Singhvi, Gautam
UNSPECIFIED
Rapalli, Vamshikrishna
UNSPECIFIED
Shukla, Shakti Dhar
UNSPECIFIED
Shastri, Madhur D.
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Khurana, Navneet
UNSPECIFIED
Awasthi, Rajendra
UNSPECIFIED
Maurya, Pawan Kumar
UNSPECIFIED
Thangavelu, Lakshmi
UNSPECIFIED
S, Rajeshkumar
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Collet, Trudi
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Last Modified: 21 Dec 2020 23:03
URI: https://eprints.centenary.org.au/id/eprint/185

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