Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate.
Full text not available from this repository.| Item Type: | Article |
|---|---|
| Official URL: | https://doi.org/10.1039/d2cc02100e |
| Journal or Publication Title: | Chemical Communications |
| Volume: | 58 |
| Number: | 49 |
| Page Range: | pp. 6890-6893 |
| Date: | 16 June 2022 |
| Divisions: | Tuberculosis |
| Depositing User: | General Admin |
| Identification Number: | 10.1039/d2cc02100e |
| ISSN: | 1359-7345 |
| Date Deposited: | 08 Jan 2023 23:06 |
| Abstract: | The covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases. Herein, we describe the conjugation of a mycobacterial peptide antigen from the 6 kDa early secretory antigenic target (ESAT6) to a suitably functionalised trehalose dibehenate (TDB), a potent glycolipid adjuvant targeting macrophage inducible C-type lectin (Mincle). |
| Creators: | Creators Email Hanna, Cameron C. UNSPECIFIED Maxwell, Joshua W. C. UNSPECIFIED Ismanto, Hendra S. UNSPECIFIED Ashhurst, Anneliese S. UNSPECIFIED Artner, Lukas M. UNSPECIFIED Rudrawar, Santosh UNSPECIFIED Britton, Warwick J. UNSPECIFIED Yamasaki, Sho UNSPECIFIED Payne, Richard J. UNSPECIFIED |
| Last Modified: | 08 Jan 2023 23:06 |
| URI: | https://eprints.centenary.org.au/id/eprint/1307 |
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