Understanding the pathogenesis of occupational coal and silica dust-associated lung disease

Understanding the pathogenesis of occupational coal and silica dust-associated lung disease.

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Item Type: Review
Official URL: https://doi.org/10.1183/16000617.0250-2021
Journal or Publication Title: European Respiratory Review
Volume: 31
Number: 165
Page Range: p. 210250
Date: 12 July 2022
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1183/16000617.0250-2021
ISSN: 0905-9180
Date Deposited: 08 Jan 2023 22:45

Workers in the mining and construction industries are at increased risk of respiratory and other diseases as a result of being exposed to harmful levels of airborne particulate matter (PM) for extended periods of time. While clear links have been established between PM exposure and the development of occupational lung disease, the mechanisms are still poorly understood. A greater understanding of how exposures to different levels and types of PM encountered in mining and construction workplaces affect pathophysiological processes in the airways and lungs and result in different forms of occupational lung disease is urgently required. Such information is needed to inform safe exposure limits and monitoring guidelines for different types of PM and development of biomarkers for earlier disease diagnosis. Suspended particles with a 50% cut-off aerodynamic diameter of 10 µm and 2.5 µm are considered biologically active owing to their ability to bypass the upper respiratory tract's defences and penetrate deep into the lung parenchyma, where they induce potentially irreversible damage, impair lung function and reduce the quality of life. Here we review the current understanding of occupational respiratory diseases, including coal worker pneumoconiosis and silicosis, and how PM exposure may affect pathophysiological responses in the airways and lungs. We also highlight the use of experimental models for better understanding these mechanisms of pathogenesis. We outline the urgency for revised dust control strategies, and the need for evidence-based identification of safe level exposures using clinical and experimental studies to better protect workers' health.

Vanka, Kanth Swaroop
Shukla, Shakti
Gomez, Henry M.
James, Carole
Palanisami, Thava
Williams, Kenneth
Chambers, Daniel C.
Britton, Warwick J.
Ilic, Dusan
Hansbro, Philip Michael
Horvat, Jay Christopher
Last Modified: 08 Jan 2023 22:45
URI: https://eprints.centenary.org.au/id/eprint/1296

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