Treatment of infection-induced vascular pathologies is protective against persistent rough morphotype Mycobacterium abscessus infection in zebrafish

Treatment of infection-induced vascular pathologies is protective against persistent rough morphotype Mycobacterium abscessus infection in zebrafish.

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Item Type: Article
Official URL: https://doi.org/10.1016/j.micpath.2022.105590
Journal or Publication Title: Microbial Pathogenesis
Volume: 167
Page Range: p. 105590
Date: 16 May 2022
Divisions: Immune-Vascular Interactions
Tuberculosis
Depositing User: General Admin
Identification Number: 10.1016/j.micpath.2022.105590
ISSN: 08824010
Date Deposited: 08 Jan 2023 22:44
Abstract:

Mycobacterium abscessus infections are of increasing global prevalence and are often difficult to treat due to complex antibiotic resistance profiles. While there are similarities between the pathogenesis of M. abscessus and tuberculous mycobacteria, including granuloma formation and stromal remodelling, there are distinct molecular differences at the host-pathogen interface. Here we have used a zebrafish-M. abscessus model and host-directed therapies that were previously identified in the zebrafish-M. marinum model to identify potential host-directed therapies against M. abscessus infection. We find efficacy of anti-angiogenic and vascular normalizing therapies against rough M. abscessus infection, but no effect of anti-platelet drugs.

Keywords: Angiogenesis; Mycobacteria; Platelet; Vascular permeability; Zebrafish.

Creators:
Creators
Email
Kam, Julia Y.
UNSPECIFIED
Wright, Kathryn
UNSPECIFIED
Britton, Warwick J.
UNSPECIFIED
Oehlers, Stefan H.
UNSPECIFIED
Last Modified: 08 Jan 2023 22:44
URI: https://eprints.centenary.org.au/id/eprint/1288

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