Mechanisms and Active Compounds Polysaccharides and Bibenzyls of Medicinal Dendrobiums for Diabetes Management

Mechanisms and Active Compounds Polysaccharides and Bibenzyls of Medicinal Dendrobiums for Diabetes Management.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.3389/fnut.2021.811870
Journal or Publication Title: Frontiers in Nutrition
Volume: 8
Date: 28 January 2022
Divisions: Lipid Cell Biology
Depositing User: General Admin
Identification Number: 10.3389/fnut.2021.811870
ISSN: 2296-861X
Date Deposited: 25 Sep 2022 23:33
Abstract:

Background: Medicinal dendrobiums are used popularly in traditional Chinese medicine for the treatment of diabetes, while their active compounds and mechanism remain unclear. This review aimed to evaluate the mechanism and active compounds of medicinal dendrobiums in diabetes management through a systematic approach.

Methods: A systematic approach was conducted to search for the mechanism and active phytochemicals in Dendrobium responsible for anti-diabetic actions using databases PubMed, Embase, and SciFinder.

Results: Current literature indicates polysaccharides, bibenzyls, phenanthrene, and alkaloids are commonly isolated in Dendrobium genusin which polysaccharides and bibenzyls are most aboundant. Many animal studies have shown that polysaccharides from the species of Dendrobium provide with antidiabetic effects by lowering glucose level and reversing chronic inflammation of T2DM taken orally at 200 mg/kg. Dendrobium polysaccharides protect pancreatic β-cell dysfunction and insulin resistance in liver. Dendrobium polysaccharides up-regulate the abundance of short-chain fatty acid to stimulate GLP-1 secretion through gut microbiota. Bibenzyls also have great potency to inhibit the progression of the chronic inflammation in cellular studies.

Conclusion: Polysaccharides and bibenzyls are the major active compounds in medicinal dendrobiums for diabetic management through the mechanisms of lowering glucose level and reversing chronic inflammation of T2DM by modulating pancreatic β-cell dysfunction and insulin resistance in liver as a result from gut microbita regulation.

Creators:
Creators
Email
Li, Mingjian
UNSPECIFIED
Trapika, I. Gusti Surya Chandra
UNSPECIFIED
Tang, Suet Yee Sara
UNSPECIFIED
Cho, Jun-Lae
UNSPECIFIED
Qi, Yanfei
UNSPECIFIED
Li, Chun Guang
UNSPECIFIED
Li, Yujuan
UNSPECIFIED
Yao, Meicun
UNSPECIFIED
Yang, Depo
UNSPECIFIED
Liu, Bowen
UNSPECIFIED
Li, Rong
UNSPECIFIED
Yang, Ping
UNSPECIFIED
Ma, Guoyi
UNSPECIFIED
Ren, Ping
UNSPECIFIED
Huang, Xi
UNSPECIFIED
Xie, Deshan
UNSPECIFIED
Chen, Shaochao
UNSPECIFIED
Li, Min
UNSPECIFIED
Yang, Lan
UNSPECIFIED
Leng, Ping
UNSPECIFIED
Huang, Yong
UNSPECIFIED
Li, George Q.
UNSPECIFIED
Last Modified: 25 Sep 2022 23:33
URI: https://eprints.centenary.org.au/id/eprint/1242

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