Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans.
Full text not available from this repository.Item Type: | Article |
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Status: | Published |
Official URL: | https://doi.org/10.1038/s42003-021-02925-1 |
Journal or Publication Title: | Communications Biology |
Volume: | 4 |
Number: | 1 |
Date: | 2021 |
Divisions: | Gene and Stem Cell Therapy |
Depositing User: | General Admin |
Identification Number: | 10.1038/s42003-021-02925-1 |
ISSN: | 2399-3642 |
Date Deposited: | 04 Apr 2022 01:27 |
Abstract: | Nutrient acquisition is essential for all organisms. Fungi regulate their metabolism according to environmental nutrient availability through elaborate transcription regulatory programs. In filamentous fungi, a highly conserved GATA transcription factor AreA and its co-repressor NmrA govern expression of genes involved in extracellular breakdown, uptake, and metabolism of nitrogen nutrients. Here, we show that the Aspergillus nidulans PnmB protease is a moonlighting protein with extracellular and intracellular functions for nitrogen acquisition and metabolism. PnmB serves not only as a secreted protease to degrade extracellular nutrients, but also as an intracellular protease to control the turnover of the co-repressor NmrA, accelerating AreA transcriptional activation upon nitrogen starvation. PnmB expression is controlled by AreA, which activates a positive feedback regulatory loop. Hence, we uncover a regulatory mechanism in the well-established controls determining the response to nitrogen starvation, revealing functional evolution of a protease gene for transcriptional regulation and extracellular nutrient breakdown. |
Creators: | Creators Email Li, Ang UNSPECIFIED Parsania, Chirag UNSPECIFIED Tan, Kaeling UNSPECIFIED Todd, Richard B. UNSPECIFIED Wong, Koon Ho UNSPECIFIED |
Last Modified: | 04 Apr 2022 01:27 |
URI: | https://eprints.centenary.org.au/id/eprint/1238 |
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