Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans

Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1038/s42003-021-02925-1
Journal or Publication Title: Communications Biology
Volume: 4
Number: 1
Date: 2021
Divisions: Gene and Stem Cell Therapy
Depositing User: General Admin
Identification Number: 10.1038/s42003-021-02925-1
ISSN: 2399-3642
Date Deposited: 04 Apr 2022 01:27
Abstract:

Nutrient acquisition is essential for all organisms. Fungi regulate their metabolism according to environmental nutrient availability through elaborate transcription regulatory programs. In filamentous fungi, a highly conserved GATA transcription factor AreA and its co-repressor NmrA govern expression of genes involved in extracellular breakdown, uptake, and metabolism of nitrogen nutrients. Here, we show that the Aspergillus nidulans PnmB protease is a moonlighting protein with extracellular and intracellular functions for nitrogen acquisition and metabolism. PnmB serves not only as a secreted protease to degrade extracellular nutrients, but also as an intracellular protease to control the turnover of the co-repressor NmrA, accelerating AreA transcriptional activation upon nitrogen starvation. PnmB expression is controlled by AreA, which activates a positive feedback regulatory loop. Hence, we uncover a regulatory mechanism in the well-established controls determining the response to nitrogen starvation, revealing functional evolution of a protease gene for transcriptional regulation and extracellular nutrient breakdown.

Creators:
Creators
Email
Li, Ang
UNSPECIFIED
Parsania, Chirag
UNSPECIFIED
Tan, Kaeling
UNSPECIFIED
Todd, Richard B.
UNSPECIFIED
Wong, Koon Ho
UNSPECIFIED
Last Modified: 04 Apr 2022 01:27
URI: https://eprints.centenary.org.au/id/eprint/1238

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