Pidotimod increases inflammation in wounded zebrafish embryos

Pidotimod increases inflammation in wounded zebrafish embryos.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Fish & Shellfish Immunology
Volume: 120
Page Range: pp. 429-433
Date: 2022
Divisions: Tuberculosis
Depositing User: General Admin
Identification Number: 10.1016/j.fsi.2021.12.013
ISSN: 10504648
Date Deposited: 17 Mar 2022 01:17

Pidotimod (PDT) is a synthetic dipeptide molecule which can improve immune responses in mice and humans, protecting hosts from infection. However, the exact mechanism of protection remains ill-defined. The effect of pidotimod has not yet been investigated in the inflammatory response of zebrafish. In this study, we used tail wound and infection models of zebrafish to study the effect of PDT on inflammation. We found that zebrafish larvae were sensitive to PDT immersion causing toxicity at doses above 50 μg/mL. The tail wound assay showed that PDT increased the recruitment of neutrophils and macrophages to the wound site and promoted the transcription of the pro-inflammatory cytokine il1b. However, we did not observe protection of uropathogenic Escherichia coli or Mycobacterium marinum infected zebrafish larvae following PDT treatment. This study provides a new platform for PDT research, which is worthy of further research to identify further effects of PDT therapy.

Ding, Li
Luo, Kaiming
Feng, Carl G.
Oehlers, Stefan H.
Last Modified: 17 Mar 2022 01:17

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