Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne

Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.4155/tde-2021-0059
Journal or Publication Title: Therapeutic Delivery
Date: 29 November 2021
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.4155/tde-2021-0059
ISSN: 2041-5990
Date Deposited: 07 Dec 2021 09:31
Abstract:

Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management.

Keywords: P. acne; agar well diffusion method; azelaic acid; broth microdilution assay; ethosomes; skin permeation.

Creators:
Creators
Email
Bisht, Alpna
UNSPECIFIED
Hemrajani, Chetna
UNSPECIFIED
Upadhyay, Navneet
UNSPECIFIED
Nidhi, Prakriti
UNSPECIFIED
Rolta, Rajan
UNSPECIFIED
Rathore, Charul
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Dev, Kamal
UNSPECIFIED
Sourirajan, Anuradha
UNSPECIFIED
Aljabali, Alaa AA
UNSPECIFIED
Bakshi, Hamid A
UNSPECIFIED
Negi, Poonam
UNSPECIFIED
Tambuwala, Murtaza M
UNSPECIFIED
Last Modified: 07 Dec 2021 09:31
URI: https://eprints.centenary.org.au/id/eprint/1172

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