Current-status and applications of polysaccharides in drug delivery systems

Current-status and applications of polysaccharides in drug delivery systems.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1016/j.colcom.2021.100418
Journal or Publication Title: Colloid and Interface Science Communications
Volume: 42
Page Range: p. 100418
Date: May 2021
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.colcom.2021.100418
ISSN: 22150382
Date Deposited: 10 Oct 2021 09:00
Abstract:

The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharide-fabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

Creators:
Creators
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Prasher, Parteek
UNSPECIFIED
Sharma, Mousmee
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Aljabali, Alaa A.
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Anand, Krishnan
UNSPECIFIED
Sharma, Nitin
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Jha, Niraj Kumar
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Gulati, Monica
UNSPECIFIED
Singh, Sachin Kumar
UNSPECIFIED
Chellappan, Dinesh K.
UNSPECIFIED
Paudel, Keshav R.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 10 Oct 2021 09:00
URI: https://eprints.centenary.org.au/id/eprint/1124

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