CTCF as a regulator of alternative splicing: new tricks for an old player

CTCF as a regulator of alternative splicing: new tricks for an old player.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1093/nar%2Fgkab520
Journal or Publication Title: Nucleic Acids Research
Volume: 49
Number: 14
Page Range: pp. 7825-7838
Date: 20 August 2021
Divisions: Gene and Stem Cell Therapy
Cancer and Gene Regulation
Depositing User: General Admin
Identification Number: 10.1093/nar/gkab520
ISSN: 0305-1048
Date Deposited: 10 Oct 2021 10:46

Three decades of research have established the CCCTC-binding factor (CTCF) as a ubiquitously expressed chromatin organizing factor and master regulator of gene expression. A new role for CTCF as a regulator of alternative splicing (AS) has now emerged. CTCF has been directly and indirectly linked to the modulation of AS at the individual transcript and at the transcriptome-wide level. The emerging role of CTCF-mediated regulation of AS involves diverse mechanisms; including transcriptional elongation, DNA methylation, chromatin architecture, histone modifications, and regulation of splicing factor expression and assembly. CTCF thereby appears to not only co-ordinate gene expression regulation but contributes to the modulation of transcriptomic complexity. In this review, we highlight previous discoveries regarding the role of CTCF in AS. In addition, we summarize detailed mechanisms by which CTCF mediates AS regulation. We propose opportunities for further research designed to examine the possible fate of CTCF-mediated alternatively spliced genes and associated biological consequences. CTCF has been widely acknowledged as the 'master weaver of the genome'. Given its multiple connections, further characterization of CTCF's emerging role in splicing regulation might extend its functional repertoire towards a 'conductor of the splicing orchestra'.

© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

Alharbi, Adel B
Schmitz, Ulf
Bailey, Charles G
Rasko, John E J
Last Modified: 12 Oct 2021 05:24
URI: https://eprints.centenary.org.au/id/eprint/1077

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