Splice and Dice: Intronic microRNAs, Splicing and Cancer

Splice and Dice: Intronic microRNAs, Splicing and Cancer.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.3390/biomedicines9091268
Journal or Publication Title: Biomedicines
Volume: 9
Number: 9
Page Range: p. 1268
Date: 19 September 2021
Divisions: Gene and Stem Cell Therapy
Depositing User: General Admin
Identification Number: 10.3390/biomedicines9091268
ISSN: 2227-9059
Date Deposited: 10 Oct 2021 10:47

Introns span only a quarter of the human genome, yet they host around 60% of all known microRNAs. Emerging evidence indicates the adaptive advantage of microRNAs residing within introns is attributed to their complex co-regulation with transcription and alternative splicing of their host genes. Intronic microRNAs are often co-expressed with their host genes, thereby providing functional synergism or antagonism that is exploited or decoupled in cancer. Additionally, intronic microRNA biogenesis and the alternative splicing of host transcript are co-regulated and intertwined. The importance of intronic microRNAs is under-recognized in relation to the pathogenesis of cancer.

Keywords: DROSHA; alternative splicing; cancer; introns; microRNA; mirtrons; splicing factors.

Wong, Alex C. H.
Rasko, John E. J.
Last Modified: 10 Oct 2021 10:47
URI: https://eprints.centenary.org.au/id/eprint/1073

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