Splice and Dice: Intronic microRNAs, Splicing and Cancer.
Full text not available from this repository.| Item Type: | Article |
|---|---|
| Status: | Published |
| Official URL: | https://doi.org/10.3390/biomedicines9091268 |
| Journal or Publication Title: | Biomedicines |
| Volume: | 9 |
| Number: | 9 |
| Page Range: | p. 1268 |
| Date: | 19 September 2021 |
| Divisions: | Gene and Stem Cell Therapy |
| Depositing User: | General Admin |
| Identification Number: | 10.3390/biomedicines9091268 |
| ISSN: | 2227-9059 |
| Date Deposited: | 10 Oct 2021 10:47 |
| Abstract: | Introns span only a quarter of the human genome, yet they host around 60% of all known microRNAs. Emerging evidence indicates the adaptive advantage of microRNAs residing within introns is attributed to their complex co-regulation with transcription and alternative splicing of their host genes. Intronic microRNAs are often co-expressed with their host genes, thereby providing functional synergism or antagonism that is exploited or decoupled in cancer. Additionally, intronic microRNA biogenesis and the alternative splicing of host transcript are co-regulated and intertwined. The importance of intronic microRNAs is under-recognized in relation to the pathogenesis of cancer. Keywords: DROSHA; alternative splicing; cancer; introns; microRNA; mirtrons; splicing factors. |
| Creators: | Creators Email Wong, Alex C. H. UNSPECIFIED Rasko, John E. J. UNSPECIFIED |
| Last Modified: | 10 Oct 2021 10:47 |
| URI: | https://eprints.centenary.org.au/id/eprint/1073 |
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