Glucose inhibits haemostasis and accelerates diet-induced hyperlipidaemia in zebrafish larvae

Glucose inhibits haemostasis and accelerates diet-induced hyperlipidaemia in zebrafish larvae.

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Item Type: Article
Official URL:
Journal or Publication Title: Scientific Reports
Volume: 11
Number: 1
Date: 24 September 2021
Divisions: Tuberculosis
Depositing User: General Admin
Identification Number: 10.1038/s41598-021-98566-9
ISSN: 2045-2322
Date Deposited: 10 Oct 2021 10:48

Hyperglycaemia damages the microvasculature in part through the reduced recruitment of immune cells and interference with platelet signalling, leading to poor wound healing and accelerated lipid deposition in mammals. We investigated the utility of zebrafish larvae to model the effect of exogenous glucose on neutrophil and macrophage recruitment to a tail wound, wound-induced haemostasis, and chicken egg yolk feed challenge-induced hyperlipidaemia by supplementing larvae with exogenous glucose by immersion or injection. Neither method of glucose supplementation affected the recruitment of neutrophils and macrophages following tail transection. Glucose injection reduced thrombocyte retention and fibrin plug formation while only thrombocyte retention was reduced by glucose immersion following tail transection. We observed accelerated lipid accumulation in glucose-injected larvae challenged with high fat chicken egg yolk feeding. Our study identifies conserved and divergent effects of high glucose on inflammation, haemostasis, and hyperlipidaemia in zebrafish larvae compared to mammals.

Morris, Simone
Cholan, Pradeep Manuneedhi
Britton, Warwick J.
Oehlers, Stefan H.
Last Modified: 10 Oct 2021 10:48

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