Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers

Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.14309/ajg.0000000000000833
Journal or Publication Title: American Journal of Gastroenterology
Volume: 116
Number: 1
Page Range: pp. 106-115
Date: 2020
Divisions: Alcoholic Liver Disease
Depositing User: General Admin
Identification Number: 10.14309/ajg.0000000000000833
ISSN: 0002-9270
Date Deposited: 10 Jun 2021 06:43
Abstract:

Introduction: Sustained high alcohol intake is necessary but not sufficient to produce alcohol-related cirrhosis. Identification of risk factors, apart from lifetime alcohol exposure, would assist in discovery of mechanisms and prediction of risk.

Methods: We conducted a multicenter case-control study (GenomALC) comparing 1,293 cases (with alcohol-related cirrhosis, 75.6% male) and 754 controls (with equivalent alcohol exposure but no evidence of liver disease, 73.6% male). Information confirming or excluding cirrhosis, and on alcohol intake and other potential risk factors, was obtained from clinical records and by interview. Case-control differences in risk factors discovered in the GenomALC participants were validated using similar data from 407 cases and 6,573 controls from UK Biobank.

Results: The GenomALC case and control groups reported similar lifetime alcohol intake (1,374 vs 1,412 kg). Cases had a higher prevalence of diabetes (20.5% (262/1,288) vs 6.5% (48/734), P = 2.27 × 10-18) and higher premorbid body mass index (26.37 ± 0.16 kg/m2) than controls (24.44 ± 0.18 kg/m2, P = 5.77 × 10-15). Controls were significantly more likely to have been wine drinkers, coffee drinkers, smokers, and cannabis users than cases. Cases reported a higher proportion of parents who died of liver disease than controls (odds ratio 2.25 95% confidence interval 1.55-3.26). Data from UK Biobank confirmed these findings for diabetes, body mass index, proportion of alcohol as wine, and coffee consumption.

Discussion: If these relationships are causal, measures such as weight loss, intensive treatment of diabetes or prediabetic states, and coffee consumption should reduce the risk of alcohol-related cirrhosis.

Copyright © 2020 by The American College of Gastroenterology.

Creators:
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Whitfield, John B.
UNSPECIFIED
Masson, Steven
UNSPECIFIED
Liangpunsakul, Suthat
UNSPECIFIED
Mueller, Sebastian
UNSPECIFIED
Aithal, Guruprasad P.
UNSPECIFIED
Eyer, Florian
UNSPECIFIED
Gleeson, Dermot
UNSPECIFIED
Thompson, Andrew
UNSPECIFIED
Stickel, Felix
UNSPECIFIED
Soyka, Michael
UNSPECIFIED
Muellhaupt, Beat
UNSPECIFIED
Daly, Ann K.
UNSPECIFIED
Cordell, Heather J.
UNSPECIFIED
Foroud, Tatiana
UNSPECIFIED
Lumeng, Lawrence
UNSPECIFIED
Pirmohamed, Munir
UNSPECIFIED
Nalpas, Bertrand
UNSPECIFIED
Jacquet, Jean-Marc
UNSPECIFIED
Moirand, Romain
UNSPECIFIED
Nahon, Pierre
UNSPECIFIED
Naveau, Sylvie
UNSPECIFIED
Perney, Pascal
UNSPECIFIED
Haber, Paul S.
UNSPECIFIED
Seitz, Helmut K.
UNSPECIFIED
Day, Christopher P.
UNSPECIFIED
Mathurin, Philippe
UNSPECIFIED
Morgan, Timothy R.
UNSPECIFIED
Seth, Devanshi
UNSPECIFIED
Last Modified: 10 Jun 2021 06:43
URI: https://eprints.centenary.org.au/id/eprint/1054

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