The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders

The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1002/cti2.1247
Journal or Publication Title: Clinical & Translational Immunology
Volume: 10
Number: 2
Date: 2021
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1002/cti2.1247
ISSN: 2050-0068
Date Deposited: 10 Jun 2021 06:42
Abstract:

Inflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote tissue healing. However, dysregulation in the immune system elicits excess/abnormal inflammation resulting in unintended tissue damage and causes major inflammatory diseases including asthma, chronic obstructive pulmonary disease, atherosclerosis, inflammatory bowel diseases, sarcoidosis and rheumatoid arthritis. It is now widely accepted that both endoplasmic reticulum (ER) stress and inflammasomes play critical roles in activating inflammatory signalling cascades. Notably, evidence is mounting for the involvement of ER stress in exacerbating inflammasome-induced inflammatory cascades, which may provide a new axis for therapeutic targeting in a range of inflammatory disorders. Here, we comprehensively review the roles, mechanisms and interactions of both ER stress and inflammasomes, as well as their interconnected relationships in inflammatory signalling cascades. We also discuss novel therapeutic strategies that are being developed to treat ER stress- and inflammasome-related inflammatory disorders.

© 2021 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.

Creators:
Creators
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Chong, Wai Chin
UNSPECIFIED
Shastri, Madhur D
UNSPECIFIED
Peterson, Gregory M
UNSPECIFIED
Patel, Rahul P
UNSPECIFIED
Pathinayake, Prabuddha S
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Hansbro, Nicole G
UNSPECIFIED
Hsu, Alan C
UNSPECIFIED
Wark, Peter A
UNSPECIFIED
Shukla, Shakti Dhar
UNSPECIFIED
Johansen, Matt D
UNSPECIFIED
Schroder, Kate
UNSPECIFIED
Hansbro, Philip M
UNSPECIFIED
Last Modified: 10 Jun 2021 06:42
URI: https://eprints.centenary.org.au/id/eprint/1049

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