Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma

Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1038/s41467-020-20422-7
Journal or Publication Title: Nature Communications
Volume: 12
Number: 1
Date: 2021
Divisions: Liver Injury and Cancer
Depositing User: General Admin
Identification Number: 10.1038/s41467-020-20422-7
ISSN: 2041-1723
Date Deposited: 10 Jun 2021 06:41
Abstract:

The gut microbiota is reported to modulate the immune response in hepatocellular carcinoma (HCC). Here, we employ metagenomic and metabolomic studies to characterise gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) related cirrhosis, with or without HCC, and evaluate its effect on the peripheral immune response in an ex vivo model. We find that dysbiosis characterises the microbiota of patients with NAFLD-cirrhosis, with compositional and functional shifts occurring with HCC development. Gene function of the microbiota in NAFLD-HCC supports short chain fatty acid production, and this is confirmed by metabolomic studies. Ex vivo studies show that bacterial extracts from the NAFLD-HCC microbiota, but not from the control groups, elicit a T cell immunosuppressive phenotype, characterised by expansion of regulatory T cells and attenuation of CD8 + T cells. Our study suggest that the gut microbiota in NAFLD-HCC is characterised by a distinctive microbiome/metabolomic profile, and can modulate the peripheral immune response.

Creators:
Creators
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Behary, Jason
UNSPECIFIED
Amorim, Nadia
UNSPECIFIED
Jiang, Xiao-Tao
UNSPECIFIED
Raposo, Anita
UNSPECIFIED
Gong, Lan
UNSPECIFIED
McGovern, Emily
UNSPECIFIED
Ibrahim, Ragy
UNSPECIFIED
Chu, Francis
UNSPECIFIED
Stephens, Carlie
UNSPECIFIED
Jebeili, Hazem
UNSPECIFIED
Fragomeli, Vincenzo
UNSPECIFIED
Koay, Yen Chin
UNSPECIFIED
Jackson, Miriam
UNSPECIFIED
O’Sullivan, John
UNSPECIFIED
Weltman, Martin
UNSPECIFIED
McCaughan, Geoffrey
UNSPECIFIED
El-Omar, Emad
UNSPECIFIED
Zekry, Amany
UNSPECIFIED
Last Modified: 10 Jun 2021 06:41
URI: https://eprints.centenary.org.au/id/eprint/1045

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