Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine.
Full text not available from this repository.| Item Type: | Article |
|---|---|
| Status: | Published |
| Official URL: | https://doi.org/10.1016/j.vaccine.2020.11.045 |
| Journal or Publication Title: | Vaccine |
| Volume: | 39 |
| Number: | 4 |
| Page Range: | pp. 652-657 |
| Date: | 2021 |
| Divisions: | Tuberculosis |
| Depositing User: | General Admin |
| Identification Number: | 10.1016/j.vaccine.2020.11.045 |
| ISSN: | 0264410X |
| Date Deposited: | 10 Jun 2021 06:28 |
| Abstract: | Background: Bacillus Calmette-Guérin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcerans in epidemiological studies. This study aimed to quantify M. ulcerans-specific immune responses induced by BCG immunisation. Methods: Intracellular cytokine analysis of in-vitro experiments done 10 weeks after BCG immunisation in 130 Australian infants randomised to one of three BCG vaccine strains given either at birth (BCG-Denmark, BCG-Japan, or BCG-Russia) or at two months of age (BCG-Denmark). Results: Proportions of polyfunctional CD4+ T-cells were higher in M. ulcerans-stimulated compared to unstimulated control samples. These proportions were not influenced by the vaccine strain or timing of the immunisation. The M. ulcerans-specific immune responses showed similar patterns to those observed in M. tuberculosis-stimulated samples, although they were of lower magnitude. Conclusions: Our data show that BCG immunisation induces M. ulcerans-specific immune responses in infants, likely explaining the cross-protective effect observed in epidemiological studies. (ACTRN12608000227392). Keywords: Buruli ulcer; Cross-protection; Mycobacterium bovis; Mycolactone; Prevention; Randomised controlled trial. Copyright © 2020. Published by Elsevier Ltd. |
| Creators: | Creators Email Pittet, Laure F. UNSPECIFIED Tebruegge, Marc UNSPECIFIED Dutta, Binita UNSPECIFIED Donath, Susan UNSPECIFIED Messina, Nicole UNSPECIFIED Casalaz, Dan UNSPECIFIED Hanekom, Willem A. UNSPECIFIED Britton, Warwick J. UNSPECIFIED Robins-Browne, Roy UNSPECIFIED Curtis, Nigel UNSPECIFIED Ritz, Nicole UNSPECIFIED |
| Last Modified: | 10 Jun 2021 06:28 |
| URI: | https://eprints.centenary.org.au/id/eprint/1039 |
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