Journey to the Center of the Cell: Tracing the Path of AAV Transduction

Journey to the Center of the Cell: Tracing the Path of AAV Transduction.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1016/j.molmed.2020.09.010
Journal or Publication Title: Trends in Molecular Medicine
Volume: 27
Number: 2
Page Range: pp. 172-184
Date: 2021
Divisions: Gene and Stem Cell Therapy
Depositing User: General Admin
Identification Number: 10.1016/j.molmed.2020.09.010
ISSN: 14714914
Date Deposited: 10 Jun 2021 06:05
Abstract:

As adeno-associated virus (AAV)-based gene therapies are being increasingly approved for use in humans, it is important that we understand vector-host interactions in detail. With the advances in genome-wide genetic screening tools, a clear picture of AAV-host interactions is beginning to emerge. Understanding these interactions can provide insights into the viral life cycle. Accordingly, novel strategies to circumvent the current limitations of AAV-based vectors may be explored. Here, we summarize our current understanding of the various stages in the journey of the vector from the cell surface to the nucleus and contextualize the roles of recently identified host factors.

Keywords: adeno-associated virus; gene therapy; transduction; viral vectors.

Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.

Creators:
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Dhungel, Bijay P.
UNSPECIFIED
Bailey, Charles G.
UNSPECIFIED
Rasko, John E.J.
UNSPECIFIED
Last Modified: 10 Jun 2021 06:05
URI: https://eprints.centenary.org.au/id/eprint/1027

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