Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validation

Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validation.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.4155/fmc-2020-0297
Journal or Publication Title: Future Medicinal Chemistry
Volume: 13
Number: 6
Page Range: pp. 543-549
Date: 2021
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.4155/fmc-2020-0297
ISSN: 1756-8919
Date Deposited: 10 Jun 2021 06:05
Abstract:

Aim: In the present study, the inhibitory potential of rutin-loaded liquid crystalline nanoparticles (LCNs) on oxidative stress was determined in human bronchial epithelial cells (BEAS-2B) by analysing the expression levels of different antioxidant (NADPH quinine oxidoreductase-1 (NQO1); γ-glutamyl cysteine synthetase catalytic subunit (GCLC)) and pro-oxidant (NADPH oxidase (Nox)-4; Nox2B) genes. Results: Our findings revealed that the rutin-loaded LCNs inhibited the genes, namely Nox2B and Nox4, which caused oxidative stress. In addition, these nanoparticles demonstrated an upregulation in the expression of the antioxidant genes Gclc and Nqo-1 in a dose-dependent manner. Conclusion: The study indicates the promising potential of rutin-loaded LCNs as an effective treatment strategy in patients with high oxidant loads in various respiratory diseases.

Creators:
Creators
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Mehta, Meenu
UNSPECIFIED
Paudel, Keshav Raj
UNSPECIFIED
Shukla, Shakti D
UNSPECIFIED
Shastri, Madhur D
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Singh, Sachin Kumar
UNSPECIFIED
Gulati, Monica
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Zacconi, Flavia C
UNSPECIFIED
Hansbro, Philip M
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 10 Jun 2021 06:05
URI: https://eprints.centenary.org.au/id/eprint/1023

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