Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.xcrm.2021.100208
Journal or Publication Title: Cell Reports Medicine
Volume: 2
Number: 3
Page Range: p. 100208
Date: 2021
Divisions: Science Support
Liver Injury and Cancer
Depositing User: General Admin
Identification Number: 10.1016/j.xcrm.2021.100208
ISSN: 26663791
Date Deposited: 09 Jun 2021 23:42
Abstract:

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or convalescent time points, up to 102 days after symptom onset, quantifying 184 immunological parameters. Acute COVID-19 presented with high levels of IL-6, IL-18, and IL-10 and broad activation marked by the upregulation of CD38 on innate and adaptive lymphocytes and myeloid cells. Importantly, activated CXCR3+cTFH1 cells in acute COVID-19 significantly correlate with and predict antibody levels and their avidity at convalescence as well as acute neutralization activity. Strikingly, intensive care unit (ICU) patients with severe COVID-19 display higher levels of soluble IL-6, IL-6R, and IL-18, and hyperactivation of innate, adaptive, and myeloid compartments than patients with moderate disease. Our analyses provide a comprehensive map of longitudinal immunological responses in COVID-19 patients and integrate key cellular pathways of complex immune networks underpinning severe COVID-19, providing important insights into potential biomarkers and immunotherapies.

Creators:
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Koutsakos, Marios
UNSPECIFIED
Rowntree, Louise C.
UNSPECIFIED
Hensen, Luca
UNSPECIFIED
Chua, Brendon Y.
UNSPECIFIED
van de Sandt, Carolien E.
UNSPECIFIED
Habel, Jennifer R.
UNSPECIFIED
Zhang, Wuji
UNSPECIFIED
Jia, Xiaoxiao
UNSPECIFIED
Kedzierski, Lukasz
UNSPECIFIED
Ashhurst, Thomas M.
UNSPECIFIED
Putri, Givanna H.
UNSPECIFIED
Marsh-Wakefield, Felix
UNSPECIFIED
Read, Mark N.
UNSPECIFIED
Edwards, Davis N.
UNSPECIFIED
Clemens, E. Bridie
UNSPECIFIED
Wong, Chinn Yi
UNSPECIFIED
Mordant, Francesca L.
UNSPECIFIED
Juno, Jennifer A.
UNSPECIFIED
Amanat, Fatima
UNSPECIFIED
Audsley, Jennifer
UNSPECIFIED
Holmes, Natasha E.
UNSPECIFIED
Gordon, Claire L.
UNSPECIFIED
Smibert, Olivia C.
UNSPECIFIED
Trubiano, Jason A.
UNSPECIFIED
Hughes, Carly M.
UNSPECIFIED
Catton, Mike
UNSPECIFIED
Denholm, Justin T.
UNSPECIFIED
Tong, Steven Y.C.
UNSPECIFIED
Doolan, Denise L.
UNSPECIFIED
Kotsimbos, Tom C.
UNSPECIFIED
Jackson, David C.
UNSPECIFIED
Krammer, Florian
UNSPECIFIED
Godfrey, Dale I.
UNSPECIFIED
Chung, Amy W.
UNSPECIFIED
King, Nicholas J.C.
UNSPECIFIED
Lewin, Sharon R.
UNSPECIFIED
Wheatley, Adam K.
UNSPECIFIED
Kent, Stephen J.
UNSPECIFIED
Subbarao, Kanta
UNSPECIFIED
McMahon, James
UNSPECIFIED
Thevarajan, Irani
UNSPECIFIED
Nguyen, Thi H.O.
UNSPECIFIED
Cheng, Allen C.
UNSPECIFIED
Kedzierska, Katherine
UNSPECIFIED
Last Modified: 10 Jun 2021 00:01
URI: https://eprints.centenary.org.au/id/eprint/1009

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