The Impact of Ultraviolet Radiation on the Aetiology and Development of Uveal Melanoma

The Impact of Ultraviolet Radiation on the Aetiology and Development of Uveal Melanoma.

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Item Type: Review
Status: Published
Official URL:
Journal or Publication Title: Cancers
Volume: 13
Number: 7
Page Range: p. 1700
Date: 2021
Divisions: Gene and Stem Cell Therapy
Depositing User: General Admin
Identification Number: 10.3390/cancers13071700
ISSN: 2072-6694
Date Deposited: 10 Jun 2021 00:00

Uveal melanoma (UM) is currently classified by the World Health Organisation as a melanoma caused by risk factors other than cumulative solar damage. However, factors relating to ultraviolet radiation (UVR) susceptibility such as light-coloured skin and eyes, propensity to burn, and proximity to the equator, frequently correlate with higher risk of UM. These risk factors echo those of the far more common cutaneous melanoma (CM), which is widely accepted to be caused by excessive UVR exposure, suggesting a role of UVR in the development and progression of a proportion of UM. Indeed, this could mean that countries, such as Australia, with high UVR exposure and the highest incidences of CM would represent a similarly high incidence of UM if UVR exposure is truly involved. Most cases of UM lack the typical genetic mutations that are related to UVR damage, although recent evidence in a small minority of cases has shown otherwise. This review therefore reassesses statistical, environmental, anatomical, and physiological evidence for and against the role of UVR in the aetiology of UM.

Chalada, Melissa
Ramlogan-Steel, Charmaine A.
Dhungel, Bijay P.
Layton, Christopher J.
Steel, Jason C.
Last Modified: 10 Jun 2021 00:00

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